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Spatial Variation in Osteonal Bone Properties Relative to Tissue and Animal Age
Author(s) -
GourionArsiquaud Samuel,
Burket Jayme C,
Havill Lorena M,
DiCarlo Edward,
Doty Stephen B,
Mendelsohn Richard,
van der Meulen Marjolein CH,
Boskey Adele L
Publication year - 2009
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.090201
Subject(s) - osteon , bone matrix , bone tissue , osteoporosis , mineralization (soil science) , bone remodeling , matrix (chemical analysis) , anatomy , biology , chemistry , cortical bone , endocrinology , cartilage , ecology , chromatography , soil water
Little is known about osteonal bone mineral and matrix properties, although these properties are of major importance for the understanding of bone alterations related to age and bone diseases such as osteoporosis. During aging, bone undergoes modifications that compromise their structural integrity as shown clinically by the increase of fracture incidence with age. Based on Fourier transform infrared (FTIR) analysis from baboons between 0 and 32 yr of age, consistent systematic variations in bone properties as a function of tissue age are reported within osteons. The patterns observed were independent of animal age and positively correlated with bone tissue elastic behavior measured by nano‐indentation. As long as tissue age is expressed as a percentage of the entire osteon radius, osteonal analyses can be used to characterize disease changes independent of the size of the osteon. These mineral and matrix analyses can be used to explain bone fragility. The mineral content (mineral‐to‐matrix ratio) was correlated with the animal age in both old (interstitial) and newly formed bone tissue, showing for the first time that age‐related changes in BMC can be explain by an alteration in the mineralization process itself and not only by an imbalance in the remodeling process.