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Dynamic and Structural Properties of the Skeleton in Hypoparathyroidism
Author(s) -
Rubin Mishaela R,
Dempster David W,
Zhou Hua,
Shane Elizabeth,
Nickolas Thomas,
Sliney James,
Silverberg Shonni J,
Bilezikian John P
Publication year - 2008
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.080803
Subject(s) - hypoparathyroidism , iliac crest , skeleton (computer programming) , endocrinology , cancellous bone , medicine , parathyroid hormone , anatomy , calcium
Abstract Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty‐three subjects with hypoparathyroidism and 33 age‐ and sex‐matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double‐labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean ± SD; BV/TV: 23.5 ± 8 versus 19.7 ± 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 ± 37 versus 119.3 ± 21 μm, p = 0.03), and cortical width (Ct.Wi: 923.4 ± 420 versus 753.5 ± 246 μm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 ± 1.58 versus 4.27 ± 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 ± 0.014 versus 0.032 ± 0.028 μm 3 /μm 2 /d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.