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Abdominal Aortic Calcification, BMD, and Bone Microstructure: A Population‐Based Study
Author(s) -
Chow John T,
Khosla Sundeep,
Melton L Joseph,
Atkinson Elizabeth J,
Camp Jon J,
Kearns Ann E
Publication year - 2008
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.080504
Subject(s) - medicine , femoral neck , osteoporosis , bone mineral , population , calcification , bone density , quantitative computed tomography , body mass index , environmental health
To better define the relationship between vascular calcification and bone mass/structure, we assessed abdominal aortic calcification (AAC), BMD, and bone microstructure in an age‐stratified, random sample of 693 Rochester, MN, residents. Participants underwent QCT of the spine and hip and high‐resolution pQCT (HRpQCT) of the radius to define volumetric BMD (vBMD) and microstructural parameters. AAC was quantified with the Agatston scoring method. In men, AAC correlated with lower vertebral trabecular and femoral neck vBMD ( p < 0.001), but not after age or multivariable (age, body mass index, smoking status) adjustment. Separation into <50 and ≥50 yr showed this pattern only in the older men. BV/TV and Tb.Th inversely correlated with AAC in all men ( p < 0.001), and Tb.Th remained significantly correlated after age adjustment ( p < 0.05). Tb.N positively correlated with AAC in younger men ( p < 0.001) but negatively correlated in older men ( p < 0.001). The opposite was true with Tb.Sp ( p = 0.01 and p < 0.001, respectively). Lower Tb.N and higher Tb.Sp correlated with AAC in older men even after multivariable adjustment. Among all women and postmenopausal women, AAC correlated with lower vertebral and femoral neck vBMD ( p < 0.001) but not after adjustment. Lower BV/TV and Tb.Th correlated with AAC ( p = 0.03 and p = 0.04, respectively) in women, but not after adjustment. Our findings support an age‐dependent association between AAC and vBMD. We also found that AAC correlates with specific bone microstructural parameters in older men, suggesting a possible common pathogenesis for vascular calcification and deterioration in bone structure. However, sex‐specific differences exist.