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Vitamin D Endocrine Physiology
Author(s) -
Heaney Robert P
Publication year - 2007
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.07s205
Subject(s) - vitamin d and neurology , endocrine system , calcium , physiology , vitamin , calcium metabolism , hormone , endocrinology , medicine
Quantitative aspects of vitamin D 3 endocrine physiology are briefly reviewed, together with the supporting evidence. Net calcium absorption of at least 200 mg/d is required to offset typical obligatory losses and thereby to protect the skeleton. The ability of the body to regulate intestinal calcium absorption is optimal at serum 25‐hydroxyvitamin D 3 concentrations >80 nM. Vitamin D 3 inputs from all sources required to sustain such a level amount to 3600–4200 IU/d. Daily oral intakes as high as 10,000 IU are safe.