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Notochordal Inclusions in the Vertebral Bone Marrow
Author(s) -
Corsi Alessandro,
De Maio Fernando,
Mancini Federico,
Ippolito Ernesto,
Riminucci Mara,
Bianco Paolo
Publication year - 2008
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.071204
Subject(s) - osteolysis , bone marrow , lesion , pathology , medicine , anatomy , radiology
Nontumoral notochordal inclusions in vertebral bone marrow give rise to MRI‐detectable lesion without osteolysis, and their detection may cause concern or overtreatment. These lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment. We present a case of nontumoral notochordal inclusions in vertebral bone marrow, giving rise to an MRI detectable lesion without osteolysis. MRI detection of such lesions may cause concern or overtreatment. Quite distinct from chordomas, these lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment.