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Molecular Genetic Studies of Gene Identification for Osteoporosis: A 2004 Update
Author(s) -
Liu YongJun,
Shen Hui,
Xiao Peng,
Xiong DongHai,
Li LiHua,
Recker Robert R,
Deng HongWen
Publication year - 2006
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.051002
Subject(s) - computational biology , osteoporosis , dna microarray , identification (biology) , quantitative trait locus , candidate gene , biology , genome wide association study , genomics , bioinformatics , genetics , gene , genome , single nucleotide polymorphism , genotype , gene expression , botany , endocrinology
This review summarizes comprehensively the most important and representative molecular genetics studies of gene identification for osteoporosis published up to the end of December 2004. It is intended to constitute a sequential update of our previously published review covering the available data up to the end of 2002. Evidence from candidate gene association studies and genome‐wide linkage studies in humans, as well as quantitative trait locus mapping animal models are reviewed separately. Studies of transgenic and knockout mice models relevant to osteoporosis are summarized. An important extension of this update is incorporation of functional genomic studies (including DNA microarrays and proteomics) on osteogenesis and osteoporosis, in light of the rapid advances and the promising prospects of the field. Comments are made on the most notable findings and representative studies for their potential influence and implications on our present understanding of genetics of osteoporosis. The format adopted by this review should be ideal for accommodating future new advances and studies.