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Gorham‐Stout Disease—Stabilization During Bisphosphonate Treatment
Author(s) -
Hammer Fabian,
Kenn Werner,
Wesselmann Ulrich,
Hofbauer Lorenz C,
Delling Günter,
Allolio Bruno,
Arlt Wiebke
Publication year - 2005
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1359/jbmr.041113
Subject(s) - medicine , rib cage , lesion , biopsy , radiology , bisphosphonate , axial skeleton , radiological weapon , surgery , osteoporosis , pathology , anatomy
A 45‐year‐old woman presented with recent onset of left‐sided chest pain. On clinical examination, these symptoms seemed to be strictly localized to a region that was marked by a long‐standing cutaneous erythematous lesion. Laboratory results showed no gross abnormalities. Radiological imaging including conventional X‐ray, MRI scans, and 3D CT reconstruction of the rib cage revealed circumscript destruction of the left lateral ribs 9–11. Histological analysis of a rib biopsy showed angiomatous hypervascularization and intracortical fibrosis. In keeping with these findings, the patient's condition was diagnosed as Gorham‐Stout disease, a rare condition with localized, often unilateral, bone destruction. Monotherapy with bisphosphonates (pamidronate 30 mg IV every 3 months) was initiated, leading to rapid disappearance of local pain. Follow‐up over 24 months documented a stable clinical and radiological picture without evidence of progressive bone destruction.