Open AccessIssues in the Use of Human Tissues to Support Precision Medicine
Author(s) -
William E. Grizzle
Publication year - 2019
Publication title -
journal of health care for the poor and underserved
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.511
H-Index - 59
eISSN - 1548-6869
pISSN - 1049-2089
DOI - 10.1353/hpu.2019.0117
Subject(s) - precision medicine , confidentiality , medicine , informed consent , health care , cancer medicine , quality (philosophy) , certification , medical physics , family medicine , alternative medicine , cancer , pathology , computer science , philosophy , computer security , epistemology , political science , law , economics , economic growth
Precision medicine is an approach in which the characteristics of patients as well as their diseases are used to identify optimal therapy; it links researchers, patients, health care providers, and clinical laboratories. In precision medicine, specific molecular characteristics of an untreatable cancer can be targeted by specific molecular-based therapy. Access to high-quality human tissues is necessary to determine many characteristics of patients and their diseases (such as targetable molecules). There are ethical issues in using human tissues in precision medicine, including informed consent and confidentiality, optimal utilization, quality of tissues, and minimization of bias. When human tissues are obtained for patient therapy, the bioresource should be a component certified by Clinical Laboratory Improvement Amendments. For precision medicine to benefit medically underserved populations requires extensive focused research, planning, and resources, some of which are currently unavailable at rural and other sites where care is provided to underserved populations.