Open AccessThe FMR1 Premutation Phenotype and Mother-Youth Synchrony in Fragile X Syndrome
Author(s) -
Carly Moser,
Laura J. Mattie,
Leonard Abbeduto,
Jessica Klusek
Publication year - 2021
Publication title -
american journal on intellectual and developmental disabilities
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.735
H-Index - 85
eISSN - 1944-7588
pISSN - 1944-7558
DOI - 10.1352/1944-7558-126.6.443
Subject(s) - fragile x syndrome , fmr1 , psychology , developmental psychology , intervention (counseling) , anxiety , phenotype , fragile x , clinical psychology , genetics , psychiatry , biology , gene
A subset of mothers who carry the FMR1 premutation may express a unique phenotype. The relationship between the FMR1 phenotype and mother-child interaction in families with fragile X-associated disorders has not been well characterized, despite the importance of high-quality mother-child interaction for child development. This study examined the association between the FMR1 phenotype and the quality of interactions between mothers and their adolescent/young adult sons with fragile X syndrome. Mother-youth synchrony was coded from a dyadic interaction. Maternal anxiety and depression symptoms, executive function deficits, and pragmatic language difficulties were evaluated. Results indicated that pragmatic language was associated with mother-youth synchrony. These findings highlight the importance of family-centered intervention practices for families with fragile X-associated disorders.