Open AccessA glance at molecular mechanisms underlying cisplatin-induced nephrotoxicity and possible renoprotective strategies: a narrative review
Author(s) -
Bashar Adi Wahyu Pandhita,
Deliaur Ihsani Rahmi,
Nielda Kezia Sumbung,
Bernardino Matthew Waworuntu,
Regina Puspa Utami,
Melva Louisa,
Vivian Soetikno
Publication year - 2019
Publication title -
medical journal of indonesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.164
H-Index - 9
eISSN - 2252-8083
pISSN - 0853-1773
DOI - 10.13181/mji.v28i3.2690
Subject(s) - nephrotoxicity , cisplatin , pharmacology , toxicity , dna damage , reactive oxygen species , chemistry , medicine , chemotherapy , biochemistry , dna
Cisplatin is a platinum-based drug that is usually used for the treatment of many carcinomas. However, it comes with several devastating side effects, including nephrotoxicity. Cisplatin toxicity is a very complex process, which is exacerbated by the accumulation of cisplatin in renal tubular cells via passive diffusion and transporter-mediated processes. Once cisplatin enters these cells, it induces the formation of reactive oxygen species that cause cellular damage, including DNA damage, inflammation, and eventually cell death. On a small scale, these damages can be mitigated by cellular antioxidant defense mechanism. However, on a large scale, such as in chemotherapy, this defense mechanism may fail, resulting in nephrotoxicity. The current article reviews the molecular mechanisms underlying cisplatin-induced nephrotoxicity and possible renoprotective strategies to determine novel therapeutic interventions for alleviating this toxicity.