Open AccessGreen and efficient method for the synthesis of 1,5-benzodiazipines using phosphate fertilizers as catalysts under free solvent
Author(s) -
Sibous Sibous,
Touriya Ghailane,
H. Serrar,
Rachida Ghailane,
Saı̈d Boukhris,
Abdelaziz Souizi
Publication year - 2017
Publication title -
mediterranean journal of chemistry
Language(s) - English
Resource type - Journals
ISSN - 2028-3997
DOI - 10.13171/mjc61/01701181035/souizi
Subject(s) - chemistry , catalysis , solvent , phosphate , phosphate fertilizer , organic chemistry , reaction conditions , green chemistry , ammonium phosphate , combinatorial chemistry , nuclear chemistry , reaction mechanism , fertilizer
Three-component reaction in one pot transformation of aldehydes, ethylacetoacetate and o-phenylenediamine was employed for the synthesis, under solvent-free, of 1,5-benzodiazepine derivatives using fertilizers mono-ammonium phosphate (MAP), di-ammonium Phosphate (DAP) and triple super phosphate (TSP) as safe, clean, and recyclable catalysts. The synthesis method seems to be operationally simple and provides access to a variety of 1,5-benzodiazepines with excellent yields in a short reaction time.