Open AccessSynthesis of new spiroheterocycles-fused isoxazoline from 2-arylidenes-3-phenyl-1-indanones through a regio-and diastereospecific 1,3-dipolar cycloaddition
Author(s) -
Asmae Mahfoud,
Abdelali Kerbal,
Asmae Nakkabi,
Mohamed El Yazidi,
Mohamed Akhazzane,
Mohamed Bakhouch,
Youssra Kanzouai,
Rachid Bouzammit,
Ghali Al Houari
Publication year - 2021
Publication title -
mediterranean journal of chemistry
Language(s) - English
Resource type - Journals
ISSN - 2028-3997
DOI - 10.13171/mjc02105141076gh
Subject(s) - chemistry , regioselectivity , cycloaddition , 1,3 dipolar cycloaddition , dipole , stereochemistry , medicinal chemistry , organic chemistry , catalysis
New spiroisoxazolines 3 have been synthesized by 1,3-dipolar cycloaddition of arylnitrile oxides with 2-arylidenes-3-phenyl-1-indanones. The reaction occurs in a regiospecific and diastereospecific manner and leads to one cycloadduct in all the cases. The proposed structure of the obtained cycloadducts was established based on spectroscopic data and confirmed by radiocrystallographic study. The spectral data were in favor of the observed regiochemistry and diastereoselectivity of this reaction.