Open AccessThe effect of pauh kijang (Irvingia malayana Oliv ex. A. Benn) in decreasing parasitemia percentage in mice infected with Plasmodium berghei
Author(s) -
Praptiwi Praptiwi,
Chairul Chairul
Publication year - 2008
Publication title -
biodiversitas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 14
eISSN - 2085-4722
pISSN - 1412-033X
DOI - 10.13057/biodiv/d090204
Subject(s) - parasitemia , plasmodium berghei , traditional medicine , negative control , positive control , ed50 , malaria , ethanol , biology , pharmacology , chemistry , medicine , plasmodium falciparum , biochemistry , immunology , in vitro
This study was conducted to determine the influence of pauh kijang (Irvingia malayana Oliv.) stem bark ethanol extract in decreasing parasitemia in mice infected with Plasmodium berghei. Mice were divided into 6 groups as treatments: (1) negative control (CMC), pauh kijang ethanol extract with the concentration of (2)1, (3)10, (4)100, (5) 1000 mg/kg BW, and (6) quinine as positive control. The result showed that meridian effective dose (ED50) of pauh kijang ethanol extract was 36.95 mg/kg BW. Treatment of 100 mg/kg BW lowered parasitemia level by 63.8%, and this treatment did not give significant different (P>0.05) compared to positive control. The result suggests that pauh kijang ethanol extract had antiplasmodial activity since this extract reduces parasitemia more than 30%.© 2008 Jurusan Biologi FMIPA UNS SurakartaKey words: Irvingia malayana, antimalarial, malaria, ED50, plasmodium