Open AccessMolecular understanding of pharmacological treatment of osteoporosis
Author(s) -
Sakae Tanaka
Publication year - 2019
Publication title -
efort open reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.588
H-Index - 22
ISSN - 2396-7544
DOI - 10.1302/2058-5241.4.180018
Subject(s) - osteoporosis , bone remodeling , medicine , bone resorption , anabolism , bone formation , intensive care medicine , bioinformatics , biology
Osteoporosis is a serious health concern, particularly in aged societies. The burden of osteoporosis with its associated morbidity and mortality due to fracture has become a critical socioeconomic problem. Skeletal integrity is maintained through a balance of bone resorption and bone formation. The bone turnover process, called bone remodelling. Recently, a number of anti-osteoporosis drugs with excellent anti-osteoporosis and fracture effects have been developed. They are mainly classified into two groups according to their effects on bone remodelling: anti-resorptive agents and anabolic agents. Cite this article: EFORT Open Rev 2019;4:158-164. DOI: 10.1302/2058-5241.4.180018