Open AccessBone mineral as a drug-seeking moiety and a waste dump
Author(s) -
Deepak Raina,
Yang Liu,
Otto L P Jacobson,
K.E. Tanner,
Magnus Tägil,
Lars Lidgren
Publication year - 2020
Publication title -
bone and joint research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.639
H-Index - 31
ISSN - 2046-3758
DOI - 10.1302/2046-3758.910.bjr-2020-0097.r1
Subject(s) - moiety , apatite , bone mineral , chemistry , mineral , bone tissue , materials science , mineralogy , biomedical engineering , metallurgy , medicine , stereochemistry , osteoporosis
Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health. Cite this article: Bone Joint Res 2020;9(10):709–718.