Open AccessEffects of interfacial micromotions on vitality and differentiation of human osteoblasts
Author(s) -
Josefin Ziebart,
Shicai Fan,
Christoph Schulze,
Peer W. Kämmerer,
Rainer Bader,
Anika JonitzHeincke
Publication year - 2018
Publication title -
bone and joint research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.639
H-Index - 31
ISSN - 2046-3758
DOI - 10.1302/2046-3758.72.bjr-2017-0228.r1
Subject(s) - osteocalcin , osteoprotegerin , osseointegration , materials science , osteoblast , alkaline phosphatase , biomedical engineering , type i collagen , implant , chemistry , receptor , endocrinology , medicine , in vitro , biology , activator (genetics) , surgery , biochemistry , enzyme
Enhanced micromotions between the implant and surrounding bone can impair osseointegration, resulting in fibrous encapsulation and aseptic loosening of the implant. Since the effect of micromotions on human bone cells is sparsely investigated, an in vitro system, which allows application of micromotions on bone cells and subsequent investigation of bone cell activity, was developed.