Open AccessThe role of CKIP-1 in osteoporosis development and treatment
Author(s) -
Xiaoxia Peng,
Xuejun Wu,
J. Zhang,
Ge Zhang,
Gang Li,
Xinghua Pan
Publication year - 2018
Publication title -
bone and joint research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.639
H-Index - 31
ISSN - 2046-3758
DOI - 10.1302/2046-3758.72.bjr-2017-0172.r1
Subject(s) - osteoporosis , medicine , casein kinase 2 , bone formation , bone morphogenetic protein , bone morphogenetic protein 2 , protein kinase a , endocrinology , kinase , microbiology and biotechnology , chemistry , biology , biochemistry , cyclin dependent kinase 2 , gene , in vitro
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment. Cite this article: X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan. The role of CKIP-1 in osteoporosis development and treatment. Bone Joint Res 2018;7:173–178. DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1.