Open AccessAccumulation of advanced oxidation protein products contributes to age-related impairment of gap junction intercellular communication in osteocytes of male mice
Author(s) -
ChenPei D. Tu,
Siqi Lai,
Zhiwei Huang,
Guixing Cai,
Kai Zhao,
Jiawen Gao,
Wu Zhiyong,
Zhaoming Zhong
Publication year - 2022
Publication title -
bone and joint research
Language(s) - English
Resource type - Journals
ISSN - 2046-3758
DOI - 10.1302/2046-3758.117.bjr-2021-0554.r2
Subject(s) - osteocyte , nadph oxidase , apocynin , oxidative stress , chemistry , reactive oxygen species , endocrinology , medicine , nicotinamide adenine dinucleotide phosphate , microbiology and biotechnology , gap junction , mitochondrion , intracellular , osteoblast , oxidase test , biochemistry , biology , in vitro , enzyme
Gap junction intercellular communication (GJIC) in osteocytes is impaired by oxidative stress, which is associated with age-related bone loss. Ageing is accompanied by the accumulation of advanced oxidation protein products (AOPPs). However, it is still unknown whether AOPP accumulation is involved in the impairment of osteocytes' GJIC. This study aims to investigate the effect of AOPP accumulation on osteocytes' GJIC in aged male mice and its mechanism.