Open AccessFlucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration
Author(s) -
Mathias Alrø Fichtner Bendtsen,
Mats Bue,
Pelle Hanberg,
Josefine Slater,
Maja Thomassen,
Jakob Hansen,
Kjeld Søballé,
Kristina Öbrink-Hansen,
Maiken Stilling
Publication year - 2021
Publication title -
bone and joint research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.639
H-Index - 31
ISSN - 2046-3758
DOI - 10.1302/2046-3758.101.bjr-2020-0250.r1
Subject(s) - flucloxacillin , microdialysis , medicine , pharmacokinetics , minimum inhibitory concentration , cloxacillin , oral administration , anesthesia , staphylococcus aureus , perioperative , soft tissue , surgery , antibiotics , pharmacology , chemistry , biology , biochemistry , bacteria , genetics , central nervous system
Flucloxacillin is commonly administered intravenously for perioperative antimicrobial prophylaxis, while oral administration is typical for prophylaxis following smaller traumatic wounds. We assessed the time, for which the free flucloxacillin concentration was maintained above the minimum inhibitory concentration ( f T > MIC) for methicillin-susceptible Staphylococcus aureus in soft and bone tissue, after intravenous and oral administration, using microdialysis in a porcine model.