Open AccessChondrosarcoma in a paediatric population: A study of 247 cases
Author(s) -
Ai-Min Wu,
G Li,
Jingwei Zheng,
C.-H. Chen,
D Chen,
Zhiqin Qiao,
JiaGuo Zhao,
B Wang,
Fu Qiang Wen,
Shihong Sheng,
Yangyang Wu,
Niu Tian,
Zhong-Ke Lin,
Huilan Xu
Publication year - 2019
Publication title -
journal of children's orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.638
H-Index - 36
eISSN - 1863-2548
pISSN - 1863-2521
DOI - 10.1302/1863-2548.13.180109
Subject(s) - chondrosarcoma , medicine , epidemiology , stage (stratigraphy) , population , pathological , cancer , cancer registry , pelvis , pediatrics , surgery , paleontology , environmental health , biology
Purpose The aims of present study are to clarify the follow questions: 1) what constitutes paediatric chondrosarcoma?; 2) what are the effects of the demographic and tumour characteristics on survival in patients with paediatric chondrosarcoma?; 3) which prognostic factors of paediatric chondrosarcoma differ from those of the adult population, which have been reported previously?Methods Paediatric patients who were diagnosed with chondrosarcoma were searched for using the case listing session protocol of the National Cancer Institute's Surveillance, Epidemiology, and End Results 18 databases (1973 to 2014). The extracted demographic information includes: age, race, gender, year of diagnosis, tumour sites, tumour histological subtype, grade, stage and treatment.Results A total of 247 paediatric chondrosarcoma patients were extracted and included in our present study. We find that the paediatric patients have significantly better survival rates than the adult patients. The year of diagnosis, tumour sites, tumour histological subtype, grade, stage and surgery received are independent prognostic factors for the survival rate of paediatric chondrosarcoma patients, but race, gender and age are not.Conclusion The paediatric chondrosarcoma patients have better survival rates than the adults. Paediatric patients with a diagnosis at an early age, tumour site at the vertebral column and pelvis/sacrococcyx, myxoid variants, high grade, distant stage and who did not have surgery have a poorer prognosis than patients with a diagnosis at a later age, tumour site at limbs, head and base, chondrosarcoma not otherwise specified, lower grade, localized stage and who received surgery.Level of Evidence II -Prognostic Study