Open AccessSynthesis and Evaluation of Novel 4-Hydroxycoumarin Derivatives as Potential Anti-Microbial Agents
Author(s) -
Suman Yadav,
Nitin Kumar
Publication year - 2021
Publication title -
oriental journal of chemistry/oriental journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2231-5039
pISSN - 0970-020X
DOI - 10.13005/ojc/370517
Subject(s) - bacillus subtilis , chemistry , antimicrobial , staphylococcus aureus , geobase , phytochemistry , escherichia coli , pseudomonas , 4 hydroxycoumarin , fluidex , elsevier biobase , stereochemistry , food science , microbiology and biotechnology , green chemistry , bacteria , organic chemistry , biochemistry , biology , catalysis , genetics , gene , ionic liquid
Coumarins are well known for their significant biological potential against several onsets. A series of novel 4-hydroxycoumarin substituted derivatives were synthesized and screened for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeureginosa bacterial strains. The zone inhibition was observed against 10 µL against different for each compound. The outcomes of the study showed that out of 10 synthesized compounds, compound 4a, 4b, 4h, and 4j showed most significant inhibitory potential against different microbial strains. The zone of inhibition for compound 4a and 4b was found as 6.36 ± 0.162, 5.60 ± 0.049, 3.61 ± 0.176, 5.64 ± 0.021 and 7.29 ± 0.339, 5.53 ± 0.459, 3.35 ± 0.226, 5.55 ± 0.042 mm while compound 4h and 4j exhibited 7.10 ± 0.544, 5.11 ± 0.183, 3.95 ± 0.226, 4.94 ± 0.494 and 6.46 ± 1.725, 4.53 ± 0.261, 3.83 ± 0.791, 5.40 ± 0.049 mm, respectively.