Open AccessSynthesis, Characterization and Evaluate the Biological Activity of Novel Heterocyclic Derivatives from Azomethine Compounds
Author(s) -
Rasim Farraj Muslim,
Suheb Eaid Saleh
Publication year - 2019
Publication title -
oriental journal of chemistry/oriental journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2231-5039
pISSN - 0970-020X
DOI - 10.13005/ojc/350416
Subject(s) - chemistry , geobase , fluidex , green chemistry , organic chemistry , evisa , material chemistry , elemental analysis , combinatorial chemistry , supramolecular chemistry , molecule
This research includes synthesis of new seventh-membered heterocyclic derivatives as 1,3-oxazepine-dione derived from azomethine compounds. Azomethine compounds R1-R4 were synthesized by the reaction of aromatic aldehydes with primary aromatic amines. The novel of 1,3-oxazepine-dione derivatives R5-R9 were obtained from the treatment of azomethine compounds with anhydrides. The synthesized compounds were checked by TLC technique, spectral methods (FT-IR, H1-NMR) and measurements of some its physical properties. The biological activity of the heterocyclic derivatives was investigated against bacteria and fungi in vitro.