Open AccessEmulgel Approach to Formulation Development: A Review
Author(s) -
Brijesh Mahesh Patel,
Ashwin Kuchekar,
Saish Rajendra Pawar
Publication year - 2021
Publication title -
biosciences biotechnology research asia/biosciences biotechnology research asia
Language(s) - English
Resource type - Journals
eISSN - 2456-2602
pISSN - 0973-1245
DOI - 10.13005/bbra/2931
Subject(s) - pulmonary surfactant , zeta potential , skin irritation , emulsion , surface tension , bioavailability , irritation , drug , chemistry , chromatography , viscosity , materials science , pharmacology , nanotechnology , medicine , dermatology , composite material , organic chemistry , thermodynamics , physics , nanoparticle , biochemistry , immunology
Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties, such as solid, semisolid, or liquid, can be developed. The topical system is created by preparing a drug emulsion and incorporating it into an emulgel. Emulgel is a thermodynamically stable formulation with low interfacial tension that is made by combining a surfactant and a co-surfactant and has several properties such as increased permeability and good thermodynamic stability. Emulgel has a dual control and a sustained release pattern. Emulgel improves bioavailability as well as patient compliance. The pH, viscosity, particle size, zeta potential, drug content, stability study, skin irritation test, and other properties of the prepared formulation are evaluated.