Open AccessCytogenotoxic Effects of Ferula asafoetida as Homoeopathic Drug in Vicia faba
Author(s) -
Sangeeta Dayal,
Alka Noopur,
Harshal Kumar
Publication year - 2018
Publication title -
biosciences biotechnology research asia/biosciences biotechnology research asia
Language(s) - English
Resource type - Journals
eISSN - 2456-2602
pISSN - 0973-1245
DOI - 10.13005/bbra/2647
Subject(s) - vicia faba , squash , root tip , clastogen , drug , crude drug , biology , pharmacology , traditional medicine , chemistry , botany , medicine , toxicity , genotoxicity , organic chemistry
Extract of Ferula asafoetida (Heeng) is commonly used as Homoeopathic drug to cure various stomach related problems. There has been significant controversy associated with the side effects of Homoeopathic drugs. The effects of different concentrations of heeng on the chromosomes of Vicia faba was investigated. 5%, 10%, 20% & 30% of Ferula asafoetida were used for 4hrs, 8hrs, 12hrs and 24 hrs followed by acetocarmine squash procedure. All the concentrations showed mitoinhibitory effect in root tips of Vicia faba and also observed so many chromosomal aberrations (clastogenic). The most observed aberrations were sticky chromosomes, chromatin bridges, chromatin fragments and laggards at every stage of mitotic division . The result of present study clearly established the cytogenotoxic behaviour of heeng as Homoeopathic drug.