Open AccessAssessment of Genotoxic Effects of Nux Vomica as Homeopathic Drug on Mitotic Chromosomes of Vicia Faba
Author(s) -
Sangeeta Dayal,
Harshal Kumar
Publication year - 2017
Publication title -
biosciences biotechnology research asia/biosciences biotechnology research asia
Language(s) - English
Resource type - Journals
eISSN - 2456-2602
pISSN - 0973-1245
DOI - 10.13005/bbra/2597
Subject(s) - vicia faba , chromatid , biology , drug , mitosis , traditional medicine , root tip , botany , pharmacology , toxicology , medicine , chromosome , genetics , gene
Extract of Nux vomica is used as homeopathic drug to cure various nervous disorders like mental emotion epilepsy, prolepses of the rectum, hydrophobia etc. The given dose of this drug is very small because of its poisonous effect in higher dose. In the present investigation we want to assess toxic effects of Nux vomica on somatic chromosomes of Vicia faba. Four concentrations 5%, 10%, 20% and 30%, were used for the treatment of root tips of test plant. There were number of abnormalities observed like stickiness at orientation of chromosomes, un-organization of chromosomes, fragmentation during separation of chromatids, multiple chromatin bridges formation etc. These types of aberrations were increased with increased concentration and duration of treatment of this drug.