Open AccessPresepsin as a biomarker for risk stratification for acute cholangitis in emergency department: A single-center study
Author(s) -
Hanyu Zhang,
Zhaoqing Lu,
Guoxing Wang,
Miaorong Xie,
Chunsheng Li
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i32.9857
Subject(s) - medicine , procalcitonin , emergency department , white blood cell , biomarker , prospective cohort study , gastroenterology , receiver operating characteristic , sepsis , biochemistry , chemistry , psychiatry
Acute cholangitis is caused by bacterial infection and has high morbidity and mortality risk. The grade of cholangitis can guide clinical treatment from single antibiotic treatment to biliary drainage. With the introduction of white blood cell (WBC) count, C-reactive protein (CRP), and total bilirubin (T-Bil) into the diagnostic criteria and severity grading for acute cholangitis, the diagnosis rate and grading have significantly improved. However, early risk stratification assessments are challenging in the emergency department. Therefore, we hope to find an ideal predictive biomarker for cholangitis grade. Presepsin is a promising biomarker for the early diagnosis, severity, and prognosis of acute bacterial infections.