Open AccessEmerging role of long noncoding RNAs in recurrent hepatocellular carcinoma
Author(s) -
Yuan Fang,
Yang Yang,
Na Li,
Xiaoli Zhang,
Hanfei Huang
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i32.9699
Subject(s) - hepatocellular carcinoma , medicine , long non coding rna , metastasis , liver cancer , affect (linguistics) , cancer research , carcinoma , distant metastasis , cancer , bioinformatics , oncology , rna , gene , biology , genetics , linguistics , philosophy
Hepatocellular carcinoma (HCC) remains one of the most frequent types of liver cancer and is characterized by a high recurrence rate. Recent studies have proposed that long non-coding RNAs (lncRNAs) are potential biomarkers in several recurrent tumor types. It is now well understood that invasion, migration, and metastasis are important factors for tumor recurrence. Moreover, some of the known risk factors for HCC may affect the expression levels of several types of lncRNAs and thus affect the recurrence of liver cancer through lncRNA regulation. In this paper, we review the biological functions, molecular mechanisms, and roles of lncRNAs in HCC and summarize current knowledge about lncRNAs as potential biomarkers in recurrent HCC.