Open AccessMechanism of Jianpi Qingchang Huashi Recipe in treating ulcerative colitis: A study based on network pharmacology and molecular docking
Author(s) -
Lei Zheng,
Xin-Li Wen,
Yan-Cheng Dai
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i26.7653
Subject(s) - medicine , uniprot , traditional chinese medicine , systems pharmacology , kegg , ulcerative colitis , mechanism (biology) , disease , pharmacology , integrative medicine , traditional medicine , database , gene ontology , gene , alternative medicine , gene expression , drug , biology , philosophy , epistemology , biochemistry , pathology , computer science
Ulcerative colitis (UC) is a refractory intestinal disease with alternating onset and remission and a long disease course, which seriously affects the health and quality of life of patients. The goal of treatment is to control clinical symptoms, induce and maintain remission, promote mucosal healing, and reduce recurrence. Clinical trials have shown unsatisfactory clinical response rates. As a supplementary alternative medicine, traditional Chinese medicine has a rich history and has shown good results in the treatment of UC. Because of the quality of herbal medicine and other factors, the curative effect of traditional Chinese medicine is not stable enough. The mechanism underlying the effect of Jianpi Qingchang Huashi Recipe (JPQCHSR) on inducing UC mucosal healing is not clear.