Open AccessCost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer
Author(s) -
Jong Beom Kim,
Young Il Kim,
Yong Sik Yoon,
Jihun Kim,
Seo Young Park,
Jong Lyul Lee,
Chan Wook Kim,
In Ja Park,
SeokByung Lim,
Chang Sik Yu,
Jin Cheon Kim
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i24.6999
Subject(s) - medicine , colorectal cancer , dna mismatch repair , antibody , oncology , cancer , immunology
The microsatellite instability (MSI) test and immunohistochemistry (IHC) are widely used to screen DNA mismatch repair (MMR) deficiency in sporadic colorectal cancer (CRC). For IHC, a two-antibody panel of MLH1 and MSH2 or four-antibody panel of MLH1, MSH2, PMS2, and MSH6 are used. In general, MSI is known as a more accurate screening test than IHC.