Open AccessAutism with dysphasia accompanied by mental retardation caused byFOXP1exon deletion: A case report
Author(s) -
Lin Song,
Xinyu Zhou,
Wanqi Wang,
Kai Jiang
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i23.6858
Subject(s) - medicine , autism , exon , developmental disorder , pediatrics , psychiatry , audiology , genetics , gene , biology
Forkhead box protein 1 (FOXP1) (OMIM: 605515) at chromosomal region 3p14.1 plays an important regulatory role in cell development and functions by regulating genetic expression. Earlier studies have suggested that FOXP1 , an oncogene, is capable of initiating tumorigenicity depending on the cell type. FOXP1 also plays an important role in regulating the cell development and functions of the immune system, e.g. , regulating B-cell maturation and mononuclear phagocyte differentiation, and in the occurrence and development of various immune diseases. The mRNA of this gene is widely expressed in humans, and its differential expression is related to numerous diseases.