Open AccessIntestinal microbiota participates in nonalcoholic fatty liver disease progression by affecting intestinal homeostasis
Author(s) -
Yang Zhang,
Junxiang Li,
Yan Zhang,
Yunliang Wang
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i23.6654
Subject(s) - nonalcoholic fatty liver disease , medicine , gut flora , pathogenesis , homeostasis , immune system , fatty liver , inflammatory bowel disease , disease , intestinal mucosa , gastroenterology , immunology
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with a pathogenesis that has not been fully elucidated. With the development of the theory of the gut-liver axis and the deepening of related research, the role of the intestinal tract in the pathogenesis of NAFLD has been investigated more. Intestinal microbiota, intestinal metabolites, and intestinal epithelial and immune-based barriers constitute the intestinal environment, which uses crosstalk to maintain the homeostasis of the intestinal environment. This paper reviews the progress in the study of intestinal microbiota, intestinal environment, and NAFLD and suggests that repair of intestinal functional balance may be a new idea for early prevention and intervention of NAFLD.