Open AccessLow-dose clozapine-related seizure: A case report and literature review
Author(s) -
Dansheng Le,
Heng Su,
Zuwei Liao,
Enyan Yu
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i20.5611
Subject(s) - medicine , clozapine , anesthesia , intensive care medicine , schizophrenia (object oriented programming) , psychiatry
Treatment-resistant schizophrenia is a severe form of schizophrenia characterized by poor response to at least two antipsychotic drugs and is typically treated with clozapine. However, clozapine lowers the epileptic threshold, leading to seizures, which are severe side effects of antipsychotics that result in multiple complications. Clozapine-related seizures are generally considered to be dose-dependent and especially rare in the low-dose (150-300 mg/d) clozapine treated population. Due to clinical rarity, little is known about its clinical characteristics and treatment.