Open AccessSevere hyperbilirubinemia in a neonate with hereditary spherocytosis due to a de novo ankyrin mutation: A case report
Author(s) -
Junfang Wang,
Li Ma,
Xiaohui Gong,
Cheng Cai,
Jingjing Sun
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i19.5245
Subject(s) - hereditary spherocytosis , ankyrin , medicine , mutation , spherocytosis , pediatrics , genetics , immunology , gene , biology , splenectomy , spleen
Hereditary spherocytosis (HS) is a common type of hemolytic anemia caused by a red cell membrane disorder. HS type 1 (HS1) is mostly caused by mutations in ankyrin ( ANK1 ). Newborns with HS1 usually only exhibit anemia and mild jaundice. We herein report a case of HS1 and discuss its clinical characteristics.