Open AccessMyelodysplastic syndrome transformed into B-lineage acute lymphoblastic leukemia: A case report
Author(s) -
Yejing Zhu,
Xiangyu Ma,
Yunliang Hao,
Yun Guan
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i19.5191
Subject(s) - medicine , lymphoblastic leukemia , myelodysplastic syndromes , lineage (genetic) , leukemia , oncology , pediatrics , bone marrow , gene , genetics , biology
Myelodysplastic syndromes (MDSs) are a group of hematological diseases caused by expansion of an abnormal clone of hematopoietic stem cells. Primary MDS is a potentially premalignant clonal disorder that may progress to overt acute leukemia in 25%-50% of cases. However, most of these cases evolve into acute myeloid leukemia and rarely progress to acute lymphoblastic leukemia (ALL). Thus, transformation of MDS into B-cell ALL is rare.