Open AccessWhy MUC16 mutations lead to a better prognosis: A study based on The Cancer Genome Atlas gastric cancer cohort
Author(s) -
Yujie Huang,
Zhifei Cao,
Jie Wang,
Jian Yang,
Yijun Wei,
Yuling Tang,
Yi Cheng,
Jian Zhou,
Zixiang Zhang
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i17.4143
Subject(s) - medicine , cohort , cancer , genome , oncology , atlas (anatomy) , genetics , gene , anatomy , biology
MUC16 , encoding cancer antigen 125, is a frequently mutated gene in gastric cancer. In addition, MUC16 mutations seem to result in a better prognosis in gastric cancer. However, the mechanisms that lead to a better prognosis by MUC16 mutations have not yet been clarified.