Nemaline myopathy with dilated cardiomyopathy and severe heart failure: A case report

Nemaline myopathy (NM) is a rare type of congenital myopathy, with an incidence of 1:50000. Patients with NM often exhibit hypomyotonia and varying degrees of muscle weakness. Skeletal muscles are always affected by this disease, while myocardial involvement is uncommon. However, with improvements in genetic testing technology, it has been found that NM with a mutation in the myopalladin ( MYPN ) gene not only causes slow, progressive muscle weakness but also results in dilated or hypertrophic cardiomyopathy.