Open AccessRelationship between mismatch repair protein, RAS, BRAF, PIK3CA gene expression and clinicopathological characteristics in elderly colorectal cancer patients
Author(s) -
Junzhen Fan,
Gao-Fei Wang,
Xuebin Cheng,
Zhouhuan Dong,
Xin Chen,
Yao Deng,
Xin Song
Publication year - 2021
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v9.i11.2458
Subject(s) - medicine , colorectal cancer , dna mismatch repair , cancer research , gene , oncology , cancer , genetics , biology
Colorectal cancer (CRC) is common in elderly patients. Mismatch repair (MMR) protein deletion is one of the causes of CRC. The RAS ( KRAS/NRAS ), BRAF , and PIK3CA genes are important gene targets in CRC treatment and are closely related to the prognosis and survival of patients. However, little is known regarding the relationship between the expression of MMR, RAS, BRAF, PIK3CA and the clinicopathological features in CRC patients.