Open AccessLiver cirrhosis in a child associated with Castleman's disease: A case report
Author(s) -
Soya Kobayashi,
Ayano Inui,
Tomoyuki Tsunoda,
Syuichiro Umetsu,
Tsuyoshi Sogo,
Masaaki Mori,
Masato Sato,
Tomoo Fujisawa
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i9.1656
Subject(s) - medicine , hepatosplenomegaly , pathology , organomegaly , anasarca , castleman disease , plasmacytosis , microcytic anemia , hypergammaglobulinemia , gastroenterology , anemia , bone marrow , disease
Castleman's disease (CD) is a lymphoproliferative disorder. TAFRO syndrome is classified as a variant of CD based on its key clinical manifestations of thrombocytopenia, anasarca (generalized edema and pleural effusion), fever (pyrexia), reticulin fibrosis in the bone marrow and the proliferation of megakaryocytes, and organomegaly (such as hepatosplenomegaly and multiple lymphadenopathies); TAFRO syndrome is mainly reported in Japanese patients. To our knowledge, this is the first pediatric case report detailing a CD-associated disorder progressing to cirrhosis.