Open AccessAzacitidine decreases reactive oxygen species production in peripheral white blood cells: A case report
Author(s) -
Hidekazu Hasunuma,
Naomi Shimizu,
Hiromitsu Yokota,
Ichiro Tatsuno
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i22.5657
Subject(s) - medicine , reactive oxygen species , peripheral blood , peripheral , white (mutation) , oxygen , biochemistry , chemistry , organic chemistry , gene
In myelodysplastic syndrome (MDS), oxidative stress is closely related to iron overload and DNA damage. A recent study suggested the possibility that increased oxidative stress causes not only iron overload but also disease progression of MDS with DNA damage. We present a case of MDS with decreased reactive oxygen species (ROS) production in peripheral white blood cells (WBCs) and decreased diacron-reactive oxygen metabolites (d-ROMs) in serum after azacitidine therapy.