Open AccessPrimary myelofibrosis with concurrent CALR and MPL mutations: A case report
Author(s) -
Fengping Zhou,
Yuming Wang,
Huaping Du,
Shanbo Cao,
Jin Zhang
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i22.5618
Subject(s) - medicine , myelofibrosis , primary (astronomy) , bone marrow , physics , astronomy
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by recurrent mutations in the JAK2 , CALR , and MPL genes. The CALR and MPL co-mutation is very rare. To our knowledge, no more than five cases have been reported. Here, we report a case of PMF in which a CALR and MPL co-mutation was detected by next-generation sequencing (NGS) technology, and a literature review was performed.