Open AccessSuccessful treatment of relapsed acute promyelocytic leukemia with arsenic trioxide in a hemodialysis-dependent patient: A case report
Author(s) -
Hee Jeong Lee,
Sang-Gon Park
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i21.5347
Subject(s) - medicine , acute promyelocytic leukemia , pancytopenia , hemodialysis , arsenic trioxide , surgery , bone marrow , gastroenterology , retinoic acid , apoptosis , biochemistry , chemistry , gene
Arsenic trioxide (ATO) is recommended for patients who do not achieve molecular remission or who have molecular or morphologic relapse. However, there are no guidelines for adjusting ATO dosage in patients with severe renal failure or on dialysis. Herein, we report the successful treatment of relapsed acute promyelocytic leukemia (APL) in a patient on hemodialysis with ATO single agent and review the cases in literature.