Open AccessDonepezil-related inadequate neuromuscular blockade during laparoscopic surgery: A case report
Author(s) -
Eun-A Jang,
TaeYoung Kim,
Eun Joo Jung,
Seongtae Jeong,
Hong-Beom Bae,
Seongheon Lee
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i21.5341
Subject(s) - medicine , neuromuscular blockade , donepezil , blockade , laparoscopic surgery , anesthesia , surgery , laparoscopy , dementia , disease , receptor
Donepezil is an acetylcholinesterase inhibitor used to improve cognition and delay disease progression in dementia patients by increasing acetylcholine levels. This drug may potentially interact with neuromuscular blocking agents (NMBAs) that act on muscular acetylcholine receptors during general anesthesia. Herein, we present a case of inadequate neuromuscular blockade with rocuronium, a nondepolarizing NMBA, in a dementia patient who had taken donepezil.