Open AccessSystemic autoimmune abnormalities complicated by cytomegalovirus-induced hemophagocytic lymphohistiocytosis: A case report
Author(s) -
Shu-Xian Miao,
Zijuan Wu,
HuaGuo Xu
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i20.4946
Subject(s) - medicine , hemophagocytic lymphohistiocytosis , macrophage activation syndrome , cytomegalovirus , etiology , rash , disease , immunology , pediatrics , viral disease , virus , herpesviridae
Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening disorder, characterized by a hyperimmune response. The mortality is high despite progress being made in the diagnosis and treatment of the disease. HLH is traditionally divided into primary (familial or genetic) and secondary (reactive) according to the etiology. Secondary HLH (sHLH), more common in adults, is often associated with underlying conditions including severe infections, malignancies, autoimmune diseases, or other etiologies.