Open AccessTFE3-expressing malignant perivascular epithelioid cell tumor of the mesentery: A case report and review of literature
Author(s) -
Nah Ihm Kim,
Ji Shin Lee,
Yoo Duk Choi,
U Chul Ju,
Jong Hee Nam
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i18.4207
Subject(s) - perivascular epithelioid cell , medicine , pathology , mesentery , epithelioid cell , immunohistochemistry , tfe3 , stromal tumor , biology , stromal cell , biochemistry , gene expression , promoter , gene
Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor that exhibits an epithelioid and spindle cell morphology. The tumor is characterized by immunoreactivity for melanocytic and myogenic markers but can be misdiagnosed as more common tumors with similar characteristics, including gastrointestinal stroma tumors or leiomyosarcomas. Recently, a subset of PEComas has been reported to harbor a transcription factor binding to TFE3 fusion. Herein, we report a rare case of TFE3 -expressing malignant PEComa arising from the mesentery.