Open AccessRelationship between granulomatous lobular mastitis and methylene tetrahydrofolate reductase gene polymorphism
Author(s) -
Qing-Ran Lei,
Xin Yang,
Chunmei Miao,
Jinchang Wang,
Yue Yang
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i18.4017
Subject(s) - methylenetetrahydrofolate reductase , medicine , genotype , gastroenterology , allele , allele frequency , gene polymorphism , genotype frequency , pathology , immunology , gene , genetics , biology
Variations in the methylene tetrahydrofolate reductase ( MTHFR ) gene have been reported as risk factors for numerous conditions, including cardiovascular disease, thrombophilia, stroke, hypertension and pregnancy-related complications. Moreover, it was reported there is an association between breast cancer and mutations in MTHFR -C677T. However, whether there is an association between MTHFR gene polymorphism and granulomatous lobular mastitis or not has been rarely investigated.