Open AccessSix families with balanced chromosome translocation associated with reproductive risks in Hainan Province: Case reports and review of the literature
Author(s) -
Yun-Chun Chen,
Xuning Huang,
Chang-Ying Kong,
Jing Hu
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i1.222
Subject(s) - chromosomal translocation , karyotype , abortion , medicine , fetus , infertility , pregnancy , gynecology , genetics , chromosome , obstetrics , biology , gene
Balanced translocation refers to the process where breakage and reconnection of chromosomes occur at abnormal positions. As the genetic substance with balanced translocation in individuals does not change, which is usually characterized by normal phenotype and intelligence, the individuals seek medical service after many miscarriages, resulting in considerable mental and physical burdens of the family members. In the current era with rapid advances in detection technology, cytogenetic examination, as a definitive approach, still plays an essential role.