Open AccessMethotrexate-related lymphoproliferative disorders in the liver: Case presentation and mini-review
Author(s) -
Takeshi Mizusawa,
Kenya Kamimura,
Hiroki Sato,
Takafumi Suda,
Hiroyuki Fukunari,
Go Hasegawa,
Osamu Shibata,
Shinichi Morita,
Akira Sakamaki,
Junji Yokoyama,
Yu Saito,
Y Hori,
Y Maruyama,
Fumitoshi Yoshimine,
Takahiro Hoshi,
Tsutomu Kanefuji,
Mariko Kobayashi,
Shuji Terai
Publication year - 2019
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v7.i21.3553
Subject(s) - medicine , methotrexate , lymphoproliferative disorders , immunosuppression , rheumatoid arthritis , lymphoma , pathology , gastroenterology
Immunosuppression is effective in treating a number of diseases, but adverse effects such as bone marrow suppression, infection, and oncogenesis are of concern. Methotrexate is a key immunosuppressant used to treat rheumatoid arthritis. Although it is effective for many patients, various side effects have been reported, one of the most serious being methotrexate-related lymphoproliferative disorder. While this may occur in various organs, liver involvement is rare. Information on these liver lesions, including clinical characteristics, course, and imaging studies, has not been summarized to date.