Open AccessAtherosclerosis and the role of immune cells
Author(s) -
Fulya İlhan,
Sevgi Kalkanlı
Publication year - 2015
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v3.i4.345
Subject(s) - medicine , immune system , immunology , inflammation , endothelium , macrophage , toll like receptor , cell adhesion molecule , downregulation and upregulation , receptor , microbiology and biotechnology , innate immune system , biology , in vitro , gene , biochemistry
Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon (IFN)-α and β are generated upon the activation of toll-like receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immune cells in the atherosclerosis.