Open AccessEpilepsy associated tumors: Review article
Author(s) -
Marco Giulioni,
Gianluca Marucci,
Matteo Martii,
Anna Federica Marliani,
Francesco Toni,
Fiorina Bartiromo,
L. Volpi,
P. Riguzzi,
Francesca Bisulli,
Ilaria Naldi,
Roberto Michelucci,
Agostino Baruzzi,
Paolo Tinuper,
Guido Rubboli
Publication year - 2014
Publication title -
world journal of clinical cases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v2.i11.623
Subject(s) - medicine , cortical dysplasia , epilepsy , epileptogenesis , epilepsy surgery , dysplasia , malignant transformation , surgery , pathology , psychiatry
Long-term epilepsy associated tumors (LEAT) represent a well known cause of focal epilepsies. Glioneuronal tumors are the most frequent histological type consisting of a mixture of glial and neuronal elements and most commonly arising in the temporal lobe. Cortical dysplasia or other neuronal migration abnormalities often coexist. Epilepsy associated with LEAT is generally poorly controlled by antiepileptic drugs while, on the other hand, it is high responsive to surgical treatment. However the best management strategy of tumor-related focal epilepsies remains controversial representing a contemporary issues in epilepsy surgery. Temporo-mesial LEAT have a widespread epileptic network with complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy LEAT may have an excellent seizure outcome therefore surgical treatment should be offered early, irrespective of pharmacoresistance, avoiding both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of malignant transformation.