Open AccessGlucose substrate in the hydrogen breath test for gut microbiota determination: A recommended noninvasive test
Author(s) -
Qiqi Xie,
Jiafeng Wang,
Yang-Fen Zhang,
Dan Xu,
Bo Zhang,
Tinghui Li,
Zhipeng Li
Publication year - 2022
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v10.i26.9536
Subject(s) - hydrogen breath test , lactulose , medicine , small intestinal bacterial overgrowth , dysbiosis , breath test , cirrhosis , gastroenterology , gut flora , irritable bowel syndrome , immunology , disease , helicobacter pylori
Intestinal dysbiosis and small intestinal bacterial overgrowth (SIBO) are common in patients with liver cirrhosis. Existing studies have not explored the association between gut dysbiosis and SIBO. We propose some suggestions for the authors' experimental methods and concepts, and we hope these suggestions can be adopted. The hydrogen breath test is worthy of recommendation due to its high accuracy and convenient operation. We suggest changing the substrate of the hydrogen breath test from lactulose to glucose to improve the accuracy of each parameter. SIBO is a small subset of gut dysbiosis, and we propose clarifying the concept of both. SIBO may be caused by liver cirrhosis or one of the pathogeneses of gastrointestinal diseases. Therefore, interference from other gastrointestinal diseases should be excluded from this study.